A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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Working with solitary-molecule optical and AFM imaging and force-spectroscopy techniques, we search for to unravel the mechanistic facets of the structure and dynamics of chromosomes. Our investigate passions contain:
But how can morality, the dignity on the human being, my experience with the that means of existence, adhere to from the motion of atoms? A purely naturalistic perspective fails in this article; a Christian point of view, I think, is a way more sensible way to interpret these areas of actuality.’
Back in 1991, Sumio Iijima of the NEC Corporation experienced reported the synthesis of carbon nanotubes. Band structure calculations proposed that these nanotubes could show metallic band conduction. This might be a major edge in excess of the conducting polymers we had explored, which had been, in reality, disordered semiconductors supplying simply variable-assortment hopping conductivity.
Considering the fact that 2000, Dekker has shifted the primary concentration of his work in the direction of biophysics wherever he studies the Qualities of solitary biomolecules and cells utilizing the applications of nanotechnology. This transformation of discipline was pushed by his fascination with the outstanding working of biological molecular constructions, together with by the lengthy-phrase standpoint that many intriguing discoveries might be predicted During this industry.[five] Current lines of study in his biophysics group are inside the regions of:[6]
This yielded a breakthrough. In just just a few months, we were in the position to measure transportation via somebody solitary-walled carbon nanotube. Dependant on lower-temperature experiments by a superb PhD college student in my team, Sander Tans (now a valued colleague and professor at Delft University of Know-how with the Energetic study lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes were being real quantum wires with pretty lengthy (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.
Our exploration ranges with the biophysics of DNA to artificial cells and over and above. Remember to have a look beneath in the spectrum of our present tasks.
Many associated developments followed, exactly where our group set up distinct transistor variants for example solitary-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled a number of transistors into modest proof-of-theory electronic circuits.
Finding out DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.
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Bulk-surface area coupling identifies the mechanistic link amongst Min-protein styles in vivo As well as in vitro
Screening pseudotopological and nontopological styles https://www.ceesdekker.net for SMC-pushed DNA loop extrusion towards roadblock-traversal experiments
Character Physics many thanks the anonymous reviewers for his or her contribution on the peer assessment of the operate.
As an example, we look at the nucleopore advanced, a gateway amongst the cell nucleus and the cytoplasm. This is an extremely difficult method and therefore challenging to examine in a mobile, so we use biomimetics. We reconstruct holes after which insert individual things in the nucleopore complex to review transport by it at the single-molecule stage.’
‘I am driven by speculate and thoughts. On a cloth level I discover solutions in physics, but I knowledge my deepest pleasure with God. That religion also drives my science And just how I contend with people.